PL numbers are detailed under Every product or service on this Site. To search out your drugs’s PL quantity, search on the carton or bottle label, as this should have the PL range on it (normally to the back again – Examine beneath the dispensing label if essential).
You can also report side effects specifically by way of the Yellow Card Scheme at yellowcard.mhra.gov.uk. By reporting Uncomfortable side effects, you may help present more info on the safety of the medication. Report a facet influence or a product complaint
Tolerance to codeine can frequently develop with lasting use – whereby lack of impact happens. This may often cause men and women rising their dose from the drug to obtain the exact same analgesic result. This may then bring on an elevated threat of dependancy.
Post-operative use in young children There have already been studies in the revealed literature that codeine supplied submit-operatively in kids just after tonsillectomy and/or adenoidectomy for obstructive slumber apnoea, brought about unusual, but existence-threatening adverse occasions such as death (see also part 4.3). All youngsters obtained doses of codeine which were in the appropriate dose vary; having said that there was proof that these young children had been possibly extremely-rapid or considerable metabolisers in their capability to metabolise codeine to morphine.
• Never choose for more time than directed by your prescriber as getting codeine frequently for years can cause habit.
Be sure you understand how to choose this medication and what other drugs you must stay away from getting with it. See also Drug Interactions section. Get professional medical assist right away if any website of those really severe Unwanted effects arise: sluggish/shallow breathing, strange lightheadedness, critical drowsiness/dizziness, difficulty waking up.
常見之不良反應有：瘙癢、噁心、嘔吐、昏睡、口乾、瞳孔縮小、姿態性低血壓（orthostatic hypotension）、小便不暢、便秘。
The danger is larger in children who're obese or have respiratory problems, or following certain surgeries (such as tonsil/adenoid elimination). Talk with your physician or pharmacist regarding the dangers and advantages of this medication.
CYP2D6 inhibitors Codeine is metabolised because of the liver enzyme CYP2D6 to its active metabolite morphine. Medicines that inhibit CYP2D6 action may possibly decrease the analgesic influence of codeine.
Possibility from concomitant use of sedative medicines such as benzodiazepines or linked medicines: Concomitant use of Co-codamol and sedative medicines for instance benzodiazepines or related prescription drugs may possibly cause sedation, respiratory despair, coma and Demise. Because of these dangers, concomitant prescribing with these sedative medicines needs to be reserved for patients for whom alternative cure choices are impossible.
A Affected individual Information and facts Leaflet (PIL) is really a doc included in the offer of a medication that gives particular details about that medication and its use. It involves specifics of dose and administration on the medication, warnings and safeguards and probable Unwanted effects.
If a decision is produced to prescribe co-codamol concomitantly with sedative medicines, the lowest successful dose really should be used, and the length of cure really should be as limited as possible. The patients really should be adopted closely for indications where can i buy cocodamol and signs and symptoms of respiratory melancholy and sedation. During this regard, it truly is strongly encouraged to inform individuals and their caregivers to concentrate on these signs and symptoms (see section four.5).
Sadly the one method to resolve these problems is to halt the medication abruptly and sometimes go through a withdrawal time period where the complications may worsen for various days right before resolving.
You can even report Unwanted effects directly through the Yellow Card Plan at yellowcard.mhra.gov.uk. By reporting side effects, you can assist provide additional information on the protection of the drugs. Report a facet impact or an item criticism